The term was first proposed by Gray and Wheatley in 1991 for a method that could obtain unbiased estimates of the effects of cancer treatment within a family based design. Mendelian randomization is a method of using measured variation in genes of known function to examine the causal effect of a modifiable exposure on disease in observational studies.
We will also focus on the future science agenda for Mendelian Randomization. He will use examples from cancer, cardiovascular diseases and other fields to illustrate this approach ( 40 minutes)ĭiscussion: This includes Q&As with speaker about his presentation. Davey Smith will give an overview of the field of Mendelian Randomization, and the opportunities it provides for assessing causal inference in medicine and public health, some of its methodologic limitations, as well as related approaches than can contribute to precision medicine and population health.